济民药业,关爱无限 www.pidrug.com
香港济民药业微信二维码
198 9654 1773
当前位置:首页 > 药品资讯 > 精神科 > 氧异安定Clobazam(氯巴占)

氧异安定Clobazam(氯巴占)

[ 人气:139 | 日期: 2020-08-04 | 返回 | 打印 ]
氧异安定Clobazam(氯巴占)
药品名称:氧异安定Clobazam(氯巴占)
药品别名:氯巴扎姆、氯巴扎母、氯巴扎酮、氧异安定、异安定酮
英 文 名:Clobazam
药品价格:$ 美国市场售价 102.65 美元
研发公司:
适 用 症:适用于治疗对其它抗癫痫药无效的难治性癫痫
型号规格:10mg/20mg两种规格,每瓶100片装。
药品详情:

【氧异安定Clobazam(氯巴占) 简述】
 
    氧异安定,别名氯巴扎姆、氯巴扎母、氯巴扎酮、氧异安定、异安定酮,英文名Clobazam,属于一类精神类药品。


氧异安定Clobazam(氯巴占)_香港济民药业

氧异安定Clobazam(氯巴占)_香港济民药业
 
【氧异安定Clobazam(氯巴占) 适应症】
 
    氧异安定Clobazam(氯巴占)适用于治疗对其它抗癫痫药无效的难治性癫痫,可单独应用,亦可作为辅助治疗用。对复杂部分性发作继发全身性发作和 Lennox-Gas-laut综合征效果更佳。
 
【氧异安定Clobazam(氯巴占) 规格】
 
    本品为片剂,分为10mg/20mg两种规格,每瓶100片装。
 
【氧异安定Clobazam(氯巴占) 服用方法】
 
    口服:从小剂量开始,每日 20— 30mg(0.5— 1mg/kg),逐步加量。如与其它抗癫痫药合用,则应减少本品剂量,每日应用 5— 15mg(0.1— 0.3mg/kg)。
 
  如连续应用,其抗惊厥作用逐渐减弱,可采用“放假疗法”,如女性患者,在月经期发作时,可在月经来潮前 2—3天开始用药,10天后停用。
 
【氧异安定Clobazam(氯巴占) 注意事项】
 
    本品具有抗焦虑和抗惊厥作用,抗电休克作用的ED50比地西泮小而比苯巴比妥、丙戊酸钠大。治疗安全范围比地西泮、苯巴比妥、丙戊酸钠宽。口服吸收快而完全,服药 1— 3小时后达血药峰浓度,经肝脏代谢,代谢产物为 N-去甲基氧异安定,同样有抗惊厥作用,作用强度为氯巴占的 2/3。 t1/2为 60小时,如每日用药 30mg,约 6天达稳态血浓度。
 
【氧异安定Clobazam(氯巴占) 不良反应】
 
    偶见有轻度的镇静、焦躁、抑郁和肌无力。
 
【氧异安定Clobazam(氯巴占) 生产厂家】
 
    氧异安定Clobazam(氯巴占)由美国新泽西伊顿敦的子公司West-ward生产。
 
Clobazam

 
Clobazam (marketed under the brand names Frisium, Urbanol, Onfi and Tapclob ) is a benzodiazepine class medication that was patented in 1968[1] and has been marketed as an anxiolytic since 1975[2] and an anticonvulsant since 1984.[3]
 
Medical uses
 
Clobazam is used for epilepsy. It is unclear if there are any benefits to clobazam over other seizure medications for children with Rolandic epilepsy or other epileptic syndromes.[4][needs update]
 
As of 2005, clobazam is approved in Canada for add-on use in tonic-clonic, complex partial, and myoclonic seizures.[5] Clobazam is approved for adjunctive therapy in complex partial seizures[6] certain types of status epilepticus, specifically the myoclonic, myoclonic-absent, simple partial, complex partial, and tonic varieties,[7] and non-status absence seizures. It is also approved for treatment of anxiety. In India, clobazam is approved for use as an adjunctive therapy in epilepsy and in acute and chronic anxiety.[8] In Japan, clobazam is approved for adjunctive therapy in treatment-resistant epilepsy featuring complex partial seizures.[9] In New Zealand, clobazam is marketed as Frisium[10] In the United Kingdom clobazam (Frisium) is approved for short-term (2–4 weeks) relief of acute anxiety in patients who have not responded to other drugs, with or without insomnia and without uncontrolled clinical depression.[11] It was not approved in the US until October 25, 2011, when it was approved for the adjunctive treatment of seizures associated with Lennox-Gastaut Syndrome in patients 2 years of age or older.[12]
 
It is also approved for adjunctive therapy for epilepsy in patients who have not responded to first-line drugs and in children who are refractory to first-line drugs. It is not recommended for use in children between the ages of six months and three years, unless there is a compelling need.[11] In addition to epilepsy and severe anxiety, clobazam is also approved as a short-term (2–4 weeks) adjunctive agent in schizophrenia and other psychotic disorders to manage anxiety or agitation.[11]
 
Clobazam is also available as an oral suspension in the UK, under the trade name of Tapclob.
 
Clobazam is sometimes used for refractory epilepsies. However, long-term prophylactic treatment of epilepsy has considerable drawbacks, most importantly loss of antiepileptic effects due to tolerance which may render long-term therapy ineffective.[13] Other antiepileptic drugs may therefore be preferred for the long-term management of epilepsy. Furthermore, benzodiazepines have the drawback, particularly after long-term use, of causing rebound seizures upon abrupt or over-rapid discontinuation of therapy forming part of the benzodiazepine withdrawal syndrome.
 
Contraindications
 
Clobazam should be used with great care in patients with the following disorders:
  Myasthenia gravis
  Sleep apnea
  Severe liver diseases such as cirrhosis and hepatitis[14]
  Severe Respiratory Insufficiency
Benzodiazepines require special precaution if used in the elderly, during pregnancy, in children, alcohol or drug-dependent individuals and individuals with comorbid psychiatric disorders.[15]
 
Overdose
 
Overdose and intoxication with benzodiazepines, including clobazam, may lead to CNS depression, associated with drowsiness, confusion, and lethargy, possibly progressing to ataxia, respiratory depression, hypotension and rarely coma or death. The risk of a fatal outcome is increased in cases of combined poisoning with other CNS depressants, including alcohol.[18]
 
 




注:药品如有新包装,以新包装为准。以上资讯仅供医护人员内部讨论,不作任何用药依据,具体用药指引,请咨询主治医师。


如您发现本网站有文字编辑或内容错误,请点击此处发送(需要安装有foxmail或outlook支持),


或发邮件至:info@morecare.hk,香港济民药业感谢您的到访!


欢迎您添加香港济民药业微信,或在公众号内留言。

 

香港济民微信
  • 香港济民药业友情链接
  • 友情链接

联系我们:

地址:
Rm. 314, Sun Ling Plaza, 30 On Kui Street, Fanling, HONG KONG
邮箱:
info@pidrug.com
电话:
198 9654 1773
粤ICP备17150936号
香港济民药业官方网站
  • 关注我们 :
  • 香港济民药业微博
  • 关注香港济民药业博客
  • 香港济民药业微信公众号