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氟握肟氨fluvoxamine

[ 人气:103 | 日期: 2020-08-04 | 返回 | 打印 ]
氟握肟氨fluvoxamine
药品名称:氟握肟氨fluvoxamine
药品别名:三氟戊肟胺;氟戊肟胺;氟伏沙明
英 文 名:fluvoxamine
药品价格:$ 美国市场售价 20.25 美元
研发公司:
适 用 症:广泛用于治疗各种抑郁症
型号规格:片剂,每片含有效成份25mg/50mg/100mg,每瓶30片装。
药品详情:

【氟握肟氨fluvoxamine 简述】
 
    氟握肟氨fluvoxamine又名三氟戊肟胺;氟戊肟胺;氟伏沙明,具有抗抑郁作用,可抑制脑神经细胞对5-羟色胺(5-HT)的再摄取,但不影响去甲肾上腺上腺上腺素(NA)的再摄取。其优点在于既无兴奋、镇静作用,又无抗胆碱、抗组胺作用,亦不影响单胺氧化化酶(MAO)活性,对心血管系统无影响,不引起直立性低血压。

氟握肟氨fluvoxamine_香港济民药业
 
【氟握肟氨fluvoxamine 适应症】
 
    本品广泛用于治疗各种抑郁症, 能迅速减少忧郁症患者的消极观念,更适用于治疗那些自杀风险大的忧郁症患者。
 
【氟握肟氨fluvoxamine 规格】
 
    本品为片剂,每片含有效成份25mg/50mg/100mg,每瓶30片装。
 
【氟握肟氨fluvoxamine 服用方法】
 
    口服每天100~200mg,剂量超过100mg时应分次服。必要时可逐渐增加至每天300mg。 晚上1次顿服可减少副反应。
 
【氟握肟氨fluvoxamine 注意事项】
 
1.(1)癫痫患者;(2)有自杀倾向的抑郁症患者;(3)患躁狂症或处于轻度躁狂状态的患者;(4)肝、肾功能不良者;(5)孕妇;(6)哺乳期妇女。
 
2.在氟握肟氨治疗的前4周,应定期监测有无锥体外系症状。
 
3.治疗焦虑症、烦躁、失眠症时,如疗效不佳,可与苯二氮卓类合用,但禁止与单胺氧化化酶抑制药(MA0I)合用。停用氟握肟氨两周后才可用单胺氧化化酶抑制药。
  
【氟握肟氨fluvoxamine 不良反应】
 
    常见的过量反应包括昏迷、惊厥、腹泻性低钾血症、低血压、反射增强,恶心、呼吸困难、嗜睡、心动过速,震颤、呕吐。心脏反应包括心动过缓和心电图异常,如心脏骤停、Q-T间期延长、Ⅰ度房室阻滞、束支阻滞和复合节律。已有死亡的报道。

 
Fluvoxamine

 
Fluvoxamine, sold under the brand name Luvox among others, is an antidepressant of the selective serotonin reuptake inhibitor(SSRI) class which is used primarily for the treatment of obsessive–compulsive disorder (OCD),[4] and is also used to treat depression and anxiety disorders, such as panic disorder and post-traumatic stress disorder.[5] Fluvoxamine is used to treat social anxiety disorder (SAD).
 
Medical uses
 
Fluvoxamine is approved in the United States for OCD,[6] and social anxiety disorder.[7] In other countries (e.g. Australia,[8][9] the UK,[10] and Russia[11]) it also has indications for major depressive disorder. In Japan it is currently approved to treat OCD, SAD and MDD.[12][13] Fluvoxamine is indicated for children and adolescents with OCD.[14] The drug works long-term, and retains its therapeutic efficacy for at least one year.[15] It has also been found to possess some analgesic properties in line with other SSRIs and tricyclic antidepressants.[16][17][18]
 
Fluvoxamine is also effective for GAD, SAD, panic disorder and separation anxiety disorder in childrens and adolescents.[19]
 
There is tentative evidence that fluvoxamine may help some people with negative symptoms of chronic schizophrenia.[20][21]
 
Adverse effects
 
Gastrointestinal side effects are more common in those receiving fluvoxamine than with other SSRIs.[22] Otherwise, fluvoxamine's side-effect profile is very similar to other SSRIs.[1][6][8][10][23][24]
 
Common (1–10% incidence) adverse effects
 
Nausea
Vomiting
Weight loss
Yawning
Loss of appetite
Agitation
Nervousness
Anxiety
Insomnia
Somnolence
Tremor
Headache
Dizziness
Palpitations
Tachycardia (high heart rate)
Abdominal pain
Dyspepsia (indigestion)
Diarrhea
Constipation
Dry mouth
Hyperhidrosis (excess sweating)
Asthenia (weakness)
Malaise
Sexual dysfunction (including delayed ejaculation, erectile dysfunction, decreased libido, etc.)
 
Uncommon (0.1–1% incidence) adverse effects
 
Arthralgia
Hallucination
Confusional state
Extrapyramidal side effects (e.g. dystonia, parkinsonism, tremor, etc.)
Orthostatic hypotension
Cutaneous hypersensitivity reactions (e.g. oedema [buildup of fluid in the tissues], rash, pruritus)
 
Rare (0.01–0.1% incidence) adverse effects
 
Mania
Seizures
Abnormal hepatic (liver) function
Photosensitivity (being abnormally sensitive to light)
Galactorrhoea (expulsion of breast milk unrelated to pregnancy or breastfeeding)
 
Unknown frequency adverse effects
 
Hyperprolactinaemia (elevated plasma prolactin levels leading to galactorrhoea, amenorrhoea [cessation of menstrual cycles], etc.)
Bone fractures
Glaucoma
Mydriasis
Urinary incontinence
Urinary retention
Bed-wetting
Serotonin syndrome — a potentially fatal condition characterised by abrupt onset muscle rigidity, hyperthermia (elevated body temperature), rhabdomyolysis,
mental status changes (e.g. coma, hallucinations, agitation), etc.
 
Neuroleptic malignant syndrome — practically identical presentation to serotonin syndrome except with a more prolonged onset
Akathisia — a sense of inner restlessness that presents itself with the inability to stay still
Paraesthesia
Dysgeusia
Haemorrhage
Withdrawal symptoms
Weight changes
Suicidal ideation and behaviour
Violence towards others[25]
Hyponatraemia
Syndrome of inappropriate antidiuretic hormone secretion
 




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