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Viibryd(维拉佐酮[vilazodone))

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Viibryd(维拉佐酮[vilazodone))
药品名称:Viibryd(维拉佐酮[vilazodone))
药品别名:维拉佐酮
英 文 名:vilazodone
药品价格:$ 美国市场售价 290.53 美元
研发公司:
适 用 症:适用于治疗重度抑郁症(MDD)。
型号规格:片剂,每片含有效成份10mg(day1--7),20mg(day8--30),每盒2套装。
药品详情:

【适应症】
 
    本品适用于治疗重度抑郁症(MDD)。

Viibryd(维拉佐酮[vilazodone))_香港济民药业
 
【规格】
  本品为片剂,每片含有效成份10mg(day1--7),20mg(day8--30),每盒2套装。
 
【服用方法】
  推荐的剂量为每天1次,每次40mg。
 
【注意事项】
(1)临床恶化/自杀风险:监视患者临床恶化和自杀想法或行为。
(2)5-羟色胺综合征或神经阻滞剂恶性综合征[神经阻滞剂恶性综合征]:用治疗可能发生。终止和开始支持治疗。
(3)癫痫发作:用治疗可能发生。有癫痫病患者中慎用。
(4)异常出血:治疗可能增加出血的风险。伴随非甾体抗炎药(NSAIDs),阿司匹林,或影响凝血的其它药物时慎用。
(5)躁狂的激活/轻度躁狂:用治疗可能发生。筛选双相障碍(躁郁症)患者。
(6)用Viibryd治疗的终止:建议逐渐减低剂量而不是突然停止。
(7)低钠血症:伴随不适当抗利尿即使分泌综合征(SIADH)可能发生。
 
【不良反应】
  最常见不良反应(发生率≥5%和至少安慰剂率两倍)是:腹泻,恶心,呕吐,和失眠。

 
Viibryd(Vilazodone)

 
Vilazodone, sold under the brand name Viibryd among others, is a medication used to treat major depressive disorder.[1] While it was being studied for generalized anxiety disorder such research had stopped as of 2017.[3] It is taken by mouth.[1]
 
Common side effects include nausea, diarrhea, and trouble sleeping.[1] Serious side effects may include suicide in those under the age of 25, serotonin syndrome, bleeding, mania, and SIADH.[1] A withdrawal syndrome may occur if the dose is rapidly decreased.[1] Use during pregnancy and breastfeeding is not generally recommended.[4] It is in the serotonin modulator class of medications and is believed to work both as an SSRI and activator of the 5-HT1A receptor.[1]
 
Vilazodone was approved for medical use in the United States in 2011.[1] It is not approved in other countries as of 2016.[5] In the United States the wholesale cost for a month of medication is about 261 USD.[6] In 2016 it was the 278th most prescribed medication in the United States with more than a million prescriptions.[7]
 
Medical uses
 
According to two eight-week trials in adults, vilazodone has an antidepressant response after one week of treatment. After eight weeks it resulted in a 13% greater response than placebo. Remission rates, however, were not significantly different versus placebo.[8]
 
According to FDA staff, "it is unknown whether [vilazodone] has any advantages compared to other drugs in the antidepressant class."[9]
 
Development for generalized anxiety disorder has been stopped as of 2017.[3]
  
Adverse effects
 
On September 6, 2016, the FDA wrote a letter to Forest Labs about Viibryd. New warnings will be added to the Viibryd label related to a link between the drug and acute pancreatitis.[10] Acute pancreatitis can lead to serious injury and even death. Pancreatitis, especially if it reoccurs, can lead to pancreatic cancer, which is almost always fatal.
 
Additionally, it is expected that new warnings related to sleep paralysis will also be added to the Viibryd label and prescribing information. Sleep paralysis is a condition in which a person is awake but cannot move or speak. Generally, sleep paralysis occurs upon waking and lasts less than one minute. Although sleep paralysis is a serious condition, and can cause psychological harm in the most severe cases, the condition is generally not life threatening.
 
After a one-year, open-label study assessing the safety and tolerability of vilazodone in people with major depressive disorder, the most common adverse effects were diarrhea(35.7%), nausea (31.6%), and headache (20.0%); greater than 90% of these adverse effects were mild or moderate.[8] Whereas in randomized controlled trials these rates were 28%, 23.4% and 13.3%, respectively.[8] In contrast to other SSRIs, initial trials showed that vilazodone did not cause decreased sexual desire/function, which often cause people to abandon their use.[11] Incidence of adverse effects include:[2]
 
Very common adverse effects (incidence >10%)
 
§  Nausea
§  Diarrhea
§  Headache
 
Common adverse effects (1–10% incidence)
 
§  Vomiting
§  Dry mouth
§  Dizziness
§  Insomnia
 
Uncommon adverse effects (0.1–1% incidence)
 
§  Somnolence
§  Paraesthesia
§  Tremor
§  Abnormal dreams
§  Libido decreased
§  Restlessness
§  Akathisia
§  Restless legs syndrome
§  Abnormal orgasms (male persons only)
§  Delayed ejaculations (male persons only)
§  Erectile dysfunction (male persons only)
§  Fatigue
§  Feeling jittery
§  Palpitations
§  Ventricular premature contractions
§  Arthralgia
§  Increased appetite
 
Rare adverse effects (<0.1% incidence)
 
§  Serotonin syndrome—a serious adverse effect characterised by:
·         Nausea
·         Vomiting
·         Mental status change (e.g. confusion, hallucinations, agitation, coma, stupor)
·         Muscle rigidity
·         Tremor
·         Myoclonus
·         Hyperreflexia—overresponsive/overactive reflexes
·         Hyperthermia—elevated body temperature
·         Autonomic instability (e.g. tachycardia, dizziness, abnormally excessive sweating, etc.)
§  Mania/hypomania—a potentially dangerously elated/agitated mood. Every antidepressant has the potential to induce these psychiatric reactions. They are particularly problematic in those with a history of hypomania/mania such as those with bipolar disorder.[12]
 
Unknown-incidence adverse effects
 
§  Suicidal ideation—all antidepressants can cause suicidal ideation especially in young adults and adolescents under the age of 25.
§  Abnormal bleeding—the SSRIs are known for their ability to increase the incidence of gastrointestinal bleeds and other bleeding abnormalities.[12][13][14]
§  Seizures
§  Syndrome of inappropriate antidiuretic hormone secretion (SIADH)—a condition characterised by an abnormally excessive secretion of antidiuretic hormone causing potentially-fatal electrolyte abnormalities (such as hyponatraemia).
§  Hyponatraemia (a complication of the former)—low blood sodium.
 
 




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