药品详情：
【奥沙西泮oxazepam 简述】
奥沙西泮oxazepam又名去甲羟基安定、氯羟氧二氯卓、舒宁、Adumbran，Serax，Serenid，是一类精神科药品；
【奥沙西泮oxazepam 适应症】
本品为地西泮的主要代谢产物。药理作用与地西泮相似但较弱，嗜睡、共济失调等副作用较小。对焦虑、紧张、失眠、头晕以及部分神经官能症均有效。对控制癫痫大、小发作也有一定作用。口服吸收差，4小时血浓度达高峰。半衰期短，清除快。用于神经官能症、失眠及癫痫的辅助治疗。适用于老年人或肾功能不良者。
【奥沙西泮oxazepam 规格】
本品为胶囊装，每片含有效成份10mg/15mg/30mg，每瓶100粒装。
【奥沙西泮oxazepam 服用方法】
口服：每次15—30mg，1日2-3次。
【奥沙西泮oxazepam 注意事项】
片剂：每片15mg；30mg。本品为地西泮的主要代谢产物。药理作用与地西泮相似但较弱，嗜睡、共济失调等副作用较小。对焦虑、紧张、失眠、头晕以及部分神经官能症均有效。对控制癫痫大、小发作也有一定作用。口服吸收差，4小时血浓度达高峰。半衰期短，清除快。用于神经官能症、失眠及癫痫的辅助治疗。适用于老年人或肾功能不良者。
【奥沙西泮oxazepam 不良反应】
偶见恶心、头昏等反应，减量或停药后可自行消失。肝、肾功能不全者慎用。
Oxazepam
Oxazepam is a short-to-intermediate-acting benzodiazepine.[3][4] Oxazepam is used for the treatment of anxiety [5][6] and insomnia and in the control of symptoms of alcohol withdrawal syndrome.
It is a metabolite of diazepam, prazepam, and temazepam,[7] and has moderate amnesic, anxiolytic, anticonvulsant, hypnotic, sedative, and skeletal muscle relaxant properties compared to other benzodiazepines.[8]
It was patented in 1962 and approved for medical use in 1964.[9]
Medical uses
It is an intermediate-acting benzodiazepine with a slow onset of action,[10] so it is usually prescribed to individuals who have trouble staying asleep, rather than falling asleep. It is commonly prescribed for anxiety disorders with associated tension, irritability, and agitation. It is also prescribed for drug and alcohol withdrawal, and for anxiety associated with depression. Physicians may use oxazepam outside its approved indications to treat social phobia, post-traumatic stress disorder, insomnia, premenstrual syndrome, and other conditions.[11]
Contraindications
Oxazepam is contraindicated in myasthenia gravis, chronic obstructive pulmonary disease, and limited pulmonary reserve, as well as severe hepatic disease.
Overdose
Oxazepam is generally less toxic in overdose than other benzodiazepines.[17] Important factors which affect the severity of a benzodiazepine overdose include the dose ingested, the age of the patient, and health status prior to overdose. Benzodiazepine overdoses can be much more dangerous if a coingestion of other CNS depressants such as opiates or alcohol has occurred. Symptoms of an oxazepam overdose include:[18][19][20]
Respiratory depression
Excessive somnolence
Altered consciousness
Central nervous system depression
Occasionally cardiovascular and pulmonary toxicity
Rarely, deep coma
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